START STUDY VIDEO FOR DURBAN

START STUDY VIDEO FOR DURBAN


Celebrations all over the world.
Join the party of START study. Smiling day night because of INSIGHT.
A biggest question is answered now. Moving forward no turning back
is what we believe in every day. Moving heads up our temperature fine.
Because we now know the optimal time. START study ah ha
The future is brighter because of what you do. [woman] My lovely daughter,
you’ve got to be strong. Mummy, I feel so much pain in the stomach.
My legs are paralyzed. I can’t feel them anymore. Yeah, my daughter, I know.
Even your temperature is too high. But Mommy, why me?
Why did I get this HIV virus? Stop blaming yourself my daughter.
You are not the only one with HIV. What I think, when time comes
and you are put on treatment, you will be fine. But, my wife, why don’t the health workers
put my daughter on treatment? Sweetheart, it’s a rule and regulation.
When someone is tested HIV positive, he or she has to wait
until his CD4 count drops to 350. Eh, eh, eh, eh. Last time when they tested,
what was her CD4 count? She was 680 CD4 count.
We are now waiting for her CD4 count to drop to 350 for her to start treatment. [wretching] No, no, no, no, no.
We can’t wait any more. We must take my daughter to the hospital right
away. [music] A luta continua (the struggle continues) [crying] Doctor. Doctor, I can’t believe this has happened
to me. I can’t believe it. I just can’t believe this has happened to me. Mr. Kapalepale.
I’m so sorry that your cancer and kidney tests are not good.
But as a medical doctor I assure you
that we are going to do all it takes for you to be okay. Doctor, I have developed cancer and kidney
failure. Is it because I took long to start my HIV
medication? We don’t know.
Today, the twenty-fifth of January 2009, we have no medical evidence to prove that
taking long to start antiretroviral medication
can lead to kidney failure, cardiovascular diseases, liver diseases, etc.
But I am happy to tell you that there is a study which is about to begin
and it is called START study. We hope it will give us that evidence. START study?
Doctor, is it possible to get in touch with the people doing that study?
Where are they? Where can I find them? Oh, I have a business card for Dr. Jim Neaton,
the head of INSIGHT, and he enjoys interacting with community.
You can give him a call and ask all the questions you want about the
study. Thank you so much, Doctor.
I go right away. [Doctor] Adhere to your medications, and I wish you
all the best. Oh, and don’t miss your next hospital appointment. [music] A luta continua (the struggle continues) Am not afraid.
Am not afraid of you my enemy. I persist every day.
A luta continua (the struggle continues). HIV is a killer
who wants to take my precious mind away. Adhere to my treatment. Am not afraid of him. Don’t give up struggle.
Life is so sweet, marvelous. Keep up the fight.
Epidemic will end. Go know your status.
Stigma no solution. Step up the speed,
treating everyone. [woman] A luta [crowd] continua! (The struggle continues.) [woman] A luta [crowd] continua! (The struggle continues.) [woman] A luta [crowd] continua! (The struggle continues.) Dear ladies and gentlemen.
Today, the twenty-fifth of January, 2009, is a great day for all people living with
HIV. It’s the day we gather together
to give our hearts to all the 55 million people who have been infected since the epidemic. [clapping and yelling] Secondly, we need to step up the pace in everything that we do. [music] Stepping up the pace. No turning back.
Defeating the scourge together. No giving up.
No losing hope. Sharing all the challenge.
Rolling every stone to win the war.
Give it up to researchers. Stigma down.
Infection gone. Stepping up the pace. Folks.
[crowd] Yes. I’m standing right in front of you
to share with you both the good and the bad news. This morning when I visited hospital, I was saddened by the news
that I have . . . . . . cancer. [crowd] What? And my kidney is failing. [crowd] Oh no. But I’m here to tell you
I can’t lose the fight. It is very sad, my brother,
that you have cancer. But did the doctor say it’s because you took long to start your HIV medication? [music]
Nobody knows the truth, No one knows the time.
But START study of INSIGHT will surely tell the truth. [phone dialing tones] Shhh. We are calling Jim. You mean we are going to see him on TV? It’s not called TV. It is Skype! [laughter] Hello, Dr. Jim Neaton.
This is Kapalepale calling from the continent of Africa.
I’m here with a group of over 100 people living with HIV
who have many community questions they want to ask you.
First and foremost, is it true that you and your team
have started a study called START study? What is START? Kapalepale, thanks for your question about
the START study. START is a trial we’ve been talking about
for decades. We’re trying to understand when is the best
time to start antiretroviral therapy. Dr. Jim, I am Gladys Nachocha,
a pregnant mother, living with HIV. I have two questions to ask you. Why the START
study? And as a pregnant mother, can I join the study? Hi, Gladys. Yes, we are doing the START study. I am glad you’re interested. Pregnant women are not eligible for the study. If you’ve not taken antiretroviral therapy,
after you deliver your child and you’re not breastfeeding,
you may enroll in the study. But if you do not enroll in START,
we recommend you follow your local guidelines for treatment during your pregnancy. Dr. Neaton, my name is Maureen Kapakapa.
Where is the study going to be? And what are you expecting to achieve from
it? Hi, Maureen.
This study’s gonna be all over the world. We expect it’s gonna be in 35 countries
with several hundred sites, and we hope you will tell everybody about
it, because no matter where you are in the world
you may be close to a site that can participate. Dr. Neaton, my name is Rachel Kandanda.
I’m interested in knowing the safety of the participants in the START study. Hi, Rachel.
It’s a good question about monitoring safety. In any clinical trial, safety really should
be very closely monitored. So a lot of data concerning the safety of
the treatments that are being used
is being collected. And an independent data and safety monitoring
board meets at least once a year
to review the safety data to make certain that the treatments are working
as we think they should be. [clapping] [music] At what CD4 should you begin your medication? How long must you wait or you start right away?
Nobody knows the truth. No one knows the time.
But START study of INSIGHT will surely tell the truth. We have lived in the gamble without research evidence. Treated many folks without optimal time.
We can have all the answers when we believe in START of INSIGHT.
Come and join the song of START study now. Dear viewers, this is QNN, Quick News Network.
I am standing here at the Joint Clinical Research Center,
one of the sites conducting the START study. Dr. Kityo, I would like to know how many participants
did this site enroll in the START study? This is the Joint Clinical Research Center.
It’s part of the START study in Africa. We recruited 159 participants
and we are the fourth highest recruitment center in the whole study. Doctor, the community wants to know
about the safety of the participants in the START study,
mostly those in the deferred arm. The study recruited participants who had CD4s
above 500. And at the time of recruitment, our national
guidelines, also the WHO, recommended that patients start
antiretroviral therapy when their CD4s are 350 and below.
So the patients who were put in the deferred arm at the beginning of the study would not have been on treatment
according to the national guidelines. However, all participants who were randomized
to the deferred arm were monitored very closely, especially their
CD4, to ensure that if their CD4s fell to the level
where they needed to be treated, we immediately put them on treatment. Okay. Doctor, I was wondering,
how were you able to get the participants for the START study?
Did you go door to door? Did you visit other health centers?
How were you able to get all the participants? The main criteria for recruitment
was a CD4 above 500. And within the clinic, at that time,
we had many patients who were not on antiretroviral drug
but were in care. And we monitored them closely to determine
if they got their CD4s to a level where we needed to start treatment,
we provided it. So there were patients in the clinic
who were not already on treatment at that time. But we also went to other clinics
and asked them to refer patients to us
who had a CD4 above 500. We went to HIV testing centers. Those who were newly diagnosed and had their
CD4 count were also enrolled into the study.
But we also went out to communities and the furthest we went was about 70 kilometers
from this site. We went to fishing villages
especially where there was high prevalence. And we tested in these communities,
and for those that were eligible for treatment, we referred them to the center for treatment.
But for those who had their CD4 above 500 we talked to them and asked them
if they would be interested in joining the study. So we have patients coming from around Kampala, the JCRC, but we also have patients coming
from communities that are far from the JCRC. [news show intro music] [radio] Good afternoon dear listeners.
This is QNN radio with breaking news. Researchers from International Network for
Strategic Initiatives in Global HIV Trials have today released
the much awaited results of START study. Oh my God!
This is beautiful! The results of START study out? [music] Community and researchers keeping fire burning
high. Darkness no more, START is lighting the torch.
Shaping the future leaving no stone unturned. No one left aside, no sitting down.
Because nobody knows the truth. No one knows the time.
But START study of INSIGHT will surely tell the truth. Big up, big up, big up, big up, big up, study participants. Am proud of you. Big up, big up, big up, big up, big up, my
community. Am proud of you.
Big up, big up, big up, big up, study investigators. Am proud of you. The future is brighter because of what you do. Dear friends of my beautiful daughter, Doodo.
I am so sure you do know the reason as to why you are here.
Today I want us to surprise my beautiful daughter because she is making 23 years of age
and 2 years on START study which has greatly improved her life. [cheering] The person standing in front of you is my husband, is Doodo’s father. [cheering] Thank you very much.
Welcome everybody. Thank you for being good parents.
We met your daughter in the START study, and we are also participants in the START
study. [clapping] Surprise! {singing] Happy birthday to you
Happy birthday to you Happy birthday dear Doodo
Happy birthday to you. [woman shouting] You people, you people!
I have good news! I have good news! [crowd] What good news? Shhhhhh! [news show intro music] Listen. Dear listeners, we are interrupting the program
with breaking news in details. The much awaited results for Strategic Timing
of Antiretroviral Therapy study has been released by Data Safety and Monitoring
Board. Our correspondent managed to interview Dr.
Jim Neaton, the head of INSIGHT,
and this is what he had to say. This is Jim Neaton.
Very happy to talk to you. Today was a big day.
We went to a meeting in Washington, and the Data and Safety Monitoring Board told
us that we had answered the question that we
had set out to answer, that immediate therapy was superior to deferred
therapy and that we should tell the world about this
result. [music] Now I know
the benefit of my treatment. No delay,
I got to start right away. My treatment game changer.
Results of START study. Let every nation strive
to put all folks on treatment. I’ve been on radio,
listening to news. Headline was cool,
results of START study. Watching television all over the world.
Hot story is one INSIGHT’s trial. Fellows with HIV,
it’s better they start medication, not tomorrow but today.
It’s really beneficial. I command all countries,
not forgetting kingdoms, let the party begin.
Everybody knows. Now I know
the benefit of my treatment. No delay,
I got to start right away. My treatment game changer.
Results of START study. Let every nation strive
to put all folks on treatment. Dear study participants and researchers,
where would I be without your tireless energy?
You brought everlasting smile to my face. Reason to celebrate the end of misery. Yeele
maama. I desire a change
in the course of our treatment. Quick beginners cut
the risk of death and illness. Sakalameta wambeeya (let’s all use) Results of START study. Kalabakalambaala (let’s all go for) Early treatment. Now I know
the benefit of my treatment. No delay,
I got to start right away. My treatment game changer.
Results of START study. Let every nation strive
to put all folks on treatment. Ladies and gentlemen
Put your hands together and welcome the representative of International Network
for Strategic Initiatives in Global HIV Trials. Mr Bodobodoooooo
[clapping] Ha ha ha. Amazing. Great. Marvelous. Ladies and gentlemen,
today is a great day because the whole world is celebrating
the good news of the START study. As you are all aware some years back
4685 people from global communities were recruited and put in a clinical trial
to find out the health benefits of starting antiretroviral medication
versus awaiting treatment. Am happy to tell you
that the study discovered beyond reasonable doubt that it’s better for an HIV-positive person to start treatment regardless of his CD4 cell
count or health. Allow me to end my speech
by proposing a toast. Ladies and gentlemen let the party begin. Sakalameta wambeeya (let’s all use) Results of START study. Kalabakalambaala (let’s all go for) Early treatment. Now I know
the benefit of my treatment. No delay,
I got to start right away. My treatment game changer.
Results of START study. Let every nation strive
to put all folks on treatment. Now I know! [music]
We gonna end the epidemic if we believe in the good work of researchers.
Nobody can despise the work they do. They spend sleepless nights to find solutions.
This one for the researchers, Our researchers.
Good researchers. Researchers all over the world.
Researchers every part of the world.

2 Comments

  1. Supercharger Moses says:

    its exciting . Thank you so much the leadership of INSIGHT, great talents of PINA Uganda and all those folks who helped me produce this video. Alluta continua. five thousand dvd copies have been printed for you attending AIDS 2016 conference in Durban. Free not for for sale

  2. Kwagala David says:

    it's a great video, educating and making extension of HIV /AIDS information to the community

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